Home » PART 4: Intermittent Fasting: Considerations for Clinical Practice

PART 4: Intermittent Fasting: Considerations for Clinical Practice

Intermittent Fasting and Cancer Metabolism:   A Four Part Series

The OutSmart Cancer® System recommends intermittent fasting for 13 hours of calorie restriction per 24 hour cycle with the appropriate assessment, monitoring and guidance of a health care provider.

While the results are promising, it's important to note that more extensive clinical trials are needed to establish standardized guidelines for implementing IF in oncology.

Personalized approaches should be considered, as the effects of IF may vary depending on cancer type, stage, and individual patient factors.

 Therefore, personalized approaches, clinical supervision and monitoring and further research are needed to fully understand and optimize the use of IF in cancer treatment.

Intermittent fasting represents a multifaceted approach to cancer prevention and treatment, leveraging metabolic, immunological, and cellular mechanisms. As research in this field continues to evolve, IF may become an important adjunct to conventional cancer therapies and part of the OutSmart Cancer® System for Creating a

 For Part 5 simply publish the blog post but a newsletter does not have to be sent

Intermittent Fasting and Cancer Metabolism:  Selected References

Part 5: Intermittent Fasting: Selected References

  1. Anemoulis, et al. (2024). Intermittent Fasting on Cancer: An Update. EJ Clinical Medicine.
  2. de Groot, S., et al. (2022). Effect of fasting on cancer: A narrative review of scientific evidence. Nutrition Reviews, 80(10), 2159-2177.
  3. Clifton, K. D., et al. (2021). Intermittent fasting in the prevention and treatment of cancer. CA: A Cancer Journal for Clinicians, 71(6), 527-546.
  4. Ferro, K., et al. (2023). Impact of Fasting on Patients With Cancer: An Integrative Review. Clinical Journal of Oncology Nursing, 27(6), 619-625.
  5. Nencioni, A., et al. (2018). Fasting and cancer: molecular mechanisms and clinical application. Nature Reviews Cancer, 18(11), 707-719.
  6. Harvie, M., & Howell, A. (2023). Intermittent fasting interventions to leverage metabolic and circadian rhythms for cancer prevention and control. JNCI Monographs, 2023(61), 84-93.
  7. Morales-Suárez-Varela, M., et al. (2020). Effect of intermittent fasting on cancer prevention: a systematic review. European Journal of Public Health, 30(Supplement_5), ckaa166.216.
  1. Stringer, A. M., et al. (2018). Autophagy and intermittent fasting: the connection for cancer therapy? Clinics, 73(suppl 1), e814s.
  2. Longo, V. D., & Mattson, M. P. (2014). Fasting: molecular mechanisms and clinical applications. Cell metabolism, 19(2), 181-192.
  3. Brandhorst, S., & Longo, V. D. (2016). Fasting and caloric restriction in cancer prevention and treatment. Recent Results in Cancer Research, 207, 241-266.
  4. Antunes, F., et al. (2018). Autophagy and intermittent fasting: the connection for cancer therapy? Clinics, 73(suppl 1), e814s.
  5. Lee, C., & Longo, V. D. (2016). Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene, 35(15), 1475-1490.
  6. Safdie, F. M., et al. (2009). Fasting and cancer treatment in humans: A case series report. Aging (Albany NY), 1(12), 988-1007.
  7. de Groot, S., et al. (2019). Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature communications, 11(1), 3083.
  8. Freedland, S. J., et al. (2024). Researchers Look to Fasting as a Next Step in Cancer Treatment. Cedars-Sinai Discoveries.
  9. Cheng, C. W., et al. (2014). Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell stem cell, 14(6), 810-823.
  10. Di Biase, S., et al. (2016). Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Cancer cell, 30(1), 136-146.
  11. Caffa, I., et al. (2020). Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature, 583(7817), 620-624.
  12. Wei, S., et al. (2017). Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science translational medicine, 9(377), eaai8700.
  13. Buono, R., & Longo, V. D. (2018). Starvation, stress resistance, and cancer. Trends in Endocrinology & Metabolism, 29(4), 271-280.